The Complete Guide to MCAS & POTS
They react to everything, symptoms span every organ system, and nothing holds. MCAS follows a pattern. Dr. Hoffman’s complete method for recognizing it, diagnosing it and treating it in the right order, with POTS, for practitioners and for patients who want to understand their own case.
If you have been told your symptoms are unrelated, or all in your head, this is the explanation. Dr. Hoffman walks through what MCAS and POTS are, why they affect every system, how they are confirmed, and how they are treated step by step. They react to everything, their symptoms span every organ system, and nothing holds. MCAS follows a pattern. Dr. Hoffman’s method teaches you to recognize it, confirm the diagnosis, and treat it in the right order, POTS included.US$349 one-time payment
★★★★★
Jodie EilersEven if you are not a clinician, this is game changing information.
19 video lessons in three parts: the MCAS & POTS training, protocols and handouts, and questionnaires.
MCAS & POTS Deep Dive
The complete MCAS and POTS lecture from Dr. Bruce Hoffman, one of the world's leading MCAS clinicians and co-author of Consensus 2.
- Full MCAS deep dive: biology, diagnosis, and treatment
- Full POTS overview, diagnosis, and treatment sequencing
- Dr. Hoffman's supplement A, B, and C teams with dosing
- Real prescription examples from Dr. Hoffman's practice
- Low-histamine dietary protocols and MCAS-safe probiotic guide
- The Triad, Pentad, and Septad framework
- Lifetime access to lecture materials
“The program offers a thoughtful and clinically grounded framework for understanding MCAS and POTS that feels both practical and compassionate. It helps organize complex information in a way that is immediately applicable.”
Leigh GaultNurse Practitioner“I had been treating MCAS and POTS the way I was taught — very ineffectively.”
Brian DonahoeFunctional Health Practitioner“It will change the way you see clients with MCAS and help you help clients to address barriers to healing.”
Kelly SairPhysiotherapist“Even if you are not a clinician, this is game changing information.”
Jodie EilersFunctional Medicine Health Coach“Dr. Hoffman is an MCAS expert, very knowledgeable, has developed healing strategies that have worked with many patients.”
Vanessa MarsdenRN, Certified Health Coach“I really enjoyed it. I've already researched the 22 Pillars of Health and Wellbeing and am looking forward to the dietary charts. I thought it was beautifully presented.”
Nancy Black-SpuntPatientEight Topics, One Complete Picture
From the biology of mast cells to real prescription examples from Dr. Hoffman's own practice, this lecture covers the full diagnostic and treatment picture, including the POTS connection that most practitioners overlook.
01MCAS 101: What It Is and Why It's ExplodingLesson 1
- What mast cells actually do, why they become dysregulated, and why MCAS is the ultimate expression of a "stuck" Cell Danger Response in a toxic modern world. Covers the history of the diagnosis from 1869 to Consensus 2.
02Symptoms and Triggers: Every Organ, Every SystemLesson 2
- A complete organ-by-organ breakdown of MCAS symptoms across skin, GI, cardiovascular, neurological, psychiatric, musculoskeletal, hormonal, and coagulation systems, so you finally know what you're looking for in your most complex patients.
03Diagnostic Criteria: Consensus 2 in PracticeLesson 3
- The updated diagnostic framework Dr. Hoffman co-authored, including lab markers, the role of tryptase, histamine, and mediator testing, differential diagnosis (systemic mastocytosis, carcinoid, pheochromocytoma), and how to avoid misdiagnosis.
04MCAS Treatment: Diet, Supplements, MedicationsLesson 4
- The full treatment stack: Paleo-Autoimmune Low-Histamine dietary protocols, Dr. Hoffman's A, B, and C-team supplements (DAO enzymes, quercetin, PEA, NeuroProtek, Nigella sativa, and more), MCAS-safe probiotics, and compounded pharmaceutical options with real dosing examples.
05POTS: Overview and Connection to MCASLesson 5
- Why POTS and MCAS almost always co-present, how autonomic dysfunction connects to mold, Lyme, and trauma, and how to support fluid balance, vagal tone, and adrenal function so your MCAS treatment can actually hold.
06POTS Diagnosis: The Tests That MatterLesson 6
- Tilt table testing, active stand test, poor man's TTT, and the diagnostic criteria that distinguishes POTS from other forms of dysautonomia. Includes the subtypes (hyperadrenergic, neuropathic, hypovolemic) and how each shapes treatment.
07POTS Treatment: Sequencing That WorksLesson 7
- Salt loading, fluid strategies, compression, exercise rehabilitation (the CHOP protocol), beta blockers, fludrocortisone, midodrine, and the interventions Dr. Hoffman has found most effective across 30 years of complex dysautonomia cases.
08The Triad, Pentad, and SeptadLesson 8
- The framework that explains why so many complex patients have MCAS, POTS, and hypermobility (EDS) together, and how understanding this constellation changes the way you approach the whole case, not just the MCAS.
Why MCAS Is the Condition Every Practitioner Needs to Understand Right Now
It's More Common Than You Think
Up to 17% of the first-world population is estimated to have MCAS. It presents differently in every patient (skin, gut, brain, cardiovascular, neurological), which is exactly why it gets missed for years.
Treatment Has a Sequence
Mast cell activation inflames the entire system. Without controlling it first, every other therapy destabilizes the patient. This lecture teaches you exactly where MCAS sits in the treatment hierarchy, and what to address before and after it.
30 Years as the World's Leading MCAS Clinic
The Hoffman Centre is known globally as one of the top MCAS clinics in the world. Dr. Hoffman co-authored the Consensus 2 diagnostic criteria with Dr. Lawrence Afrin. This is that clinical knowledge, structured and transferred.
Defining MCAS in Complex Chronic Illness
Dr. Hoffman did not stumble into MCAS; he helped define it within the context of treating chronic complex illness and the Cell Danger Response.
- 2010
Knocking at the Door
Dr. Hoffman starts noticing more and more multi-system, multi-symptom patients whose diagnoses struggle to fit under any previously understood disease process. Something else is happening.
- 2017
The Pentad Revealed
Invited to the inaugural MCAS conference at Common Weal, San Francisco, alongside Dr. Mark Renneker and Dr. Larry Afrin. Dr. Andy Maxwell presents the concept of the triad and pentad for the first time. A new clinical framework is born.
- 2018
Now It Has a Name
Through dialogue with colleagues, Mast Cell Activation becomes the explanation for what Dr. Hoffman has been seeing for years. The Hoffman Centre begins developing its MCAS treatment approach in earnest.
- 2020
Co-Author of Consensus 2
Dr. Hoffman joins Dr. Lawrence Afrin and a core international group of physicians to co-author Consensus 2, a new global diagnostic proposal for MCAS that is still used by leading practitioners worldwide.
- 2021
MCAS and the Cell Danger Response
Dr. Hoffman connects the dots between MCAS, POTS, the Cell Danger Response, and the Health Cycle Principles, establishing a sequenced treatment approach. The Hoffman Centre becomes known as one of the top MCAS clinics in the world, drawing patients from across the globe to Calgary.
Meet Dr. Bruce Hoffman
I co-authored the global Consensus 2 diagnostic criteria for MCAS. My clinic has treated patients who flew in from six continents to be seen.
Over 30 years of treating the most complex cases in integrative medicine, MCAS became the condition I kept coming back to, because it's at the centre of almost every case that doesn't resolve. I built a sequenced approach to treating it, refined it across thousands of patients, and now I'm teaching it. I teach it as a way of understanding, not a protocol.
- Co-authored the Consensus 2 diagnostic criteria with Dr. Lawrence Afrin
- 30 years treating the most complex cases in integrative medicine
- The Hoffman Centre, Calgary
Is this for you?
This lecture is for anyone who wants to understand MCAS at the level Dr. Hoffman teaches it: from biology to bedside.
You're a perfect fit if...
- You're a practitioner with patients who react to everything and who don't have a clear framework for why
- You suspect MCAS but aren't confident in diagnosing or sequencing the treatment
- You have complex patients with POTS, hypermobility, or autoimmunity and want to understand the connection
- You want Dr. Hoffman's actual supplement stack, dietary protocols, and prescription examples
- You're a patient advocate who wants to understand your own condition at a clinical level
This isn't for you if...
- You want a one-page protocol with no explanation of why it works
- You're looking for a personal consultation or diagnosis from Dr. Hoffman
- You're unwilling to consider the environmental and systemic drivers of mast cell activation
- You want a quick fix without understanding the underlying biology
Frequently Asked Questions
Is this for practitioners only, or can patients access it too?
The lecture is primarily designed for healthcare practitioners: MDs, NDs, and allied health professionals. However, patient advocates and informed patients who want to understand their condition at a clinical depth do purchase and benefit from this material.
Is this the same content as the bonus module in the full 7 Stages curriculum?
Yes. This is Lecture 6 from the 7 Stages to Health and Transformation curriculum, the MCAS and POTS deep dive module. If you later enrol in the full curriculum, this content is included and the cost can be credited toward the full program. Contact us at support@drbrucehoffman.com for details.
How long is the lecture and how is it delivered?
The full lecture is delivered as video content with accompanying slides. You get lifetime access and can revisit specific topics any time a complex MCAS case comes through your door.
Will I be able to implement this in my practice straight away?
Yes. The lecture includes specific supplement protocols with dosing, dietary handouts, and real prescription examples from Dr. Hoffman's clinical practice. Many practitioners begin applying the diagnostic framework and treatment sequencing immediately.
What is the refund policy?
Due to the digital nature of this product, all sales are final. If you experience any issues accessing your content or believe you were charged in error, please contact us within 7 days of purchase and we will resolve the situation.
You can reach us at any time at support@drbrucehoffman.com